abstract：:Primary immune thrombocytopenia (ITP) is an autoimmune disease characterized by pathogenic immunoglobulin G (IgG) autoantibodies that bind to platelets, causing their phagocytic removal and leading to reductions in platelet number. The neonatal Fc receptor (FcRn) selectively salvages and recycles IgG, including pathog...

journal_title：International immunopharmacology

authors： Smith B,Christodoulou L,Clargo A,Eddleston A,Greenslade K,Lightwood D,Shock A,Tyson K,Brennan FR

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Primary (PID) and secondary immune deficiencies (SID) represent diverse groups of diagnoses, yet both can be effectively treated with intravenous immunoglobulin (IVIG) replacement therapy. Guidelines for the use of IVIG in SID vary due to the paucity of data. The objective was to analyze available IVIG Privigen...

journal_title：International immunopharmacology

authors： Tortorici MA,Lawo JP,Weide R,Jochems J,Puli S,Hofmann J,Pfruender D,Rojavin MA

更新日期：2019-01-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneous disorder diagnosed based on the severity of abnormalities in social skills. Several studies have acknowledged the presence of abnormal immune functions among individuals diagnosed with ASD. HLA-DR (human leukocyte antigen-antigen D related) has been shown to play a sig...

journal_title：International immunopharmacology

authors： Ahmad SF,Ansari MA,Nadeem A,Bakheet SA,Al-Ayadhi LY,Alotaibi MR,Alhoshani AR,Al-Hosaini KA,Attia SM

更新日期：2018-12-01 00:00:00

abstract：:In the pathogenesis of acute respiratory distress syndrome (ARDS), an increase in vascular endothelial permeability may trigger pulmonary edema and ultimately lead to respiratory failure. Endothelial glycocalyx damage is an important factor that causes an increase in vascular endothelial permeability. Berberine (BBR) ...

journal_title：International immunopharmacology

authors： Huang L,Zhang X,Ma X,Zhang D,Li D,Feng J,Pan X,Lü J,Wang X,Liu X

更新日期：2018-12-01 00:00:00

abstract：:Paraquat (PQ) induces acute lung injury (ALI) and immunotoxicity. Apigenin exerts anti-oxidant and anti-inflammatory properties. The purpose of this study was to investigate the possible protective effects of apigenin on PQ-induced ALI and immunotoxicity in mice. Female C57BL/6 mice received a single injection of PQ (...

journal_title：International immunopharmacology

authors： Liu Y,Li Z,Xue X,Wang Y,Zhang Y,Wang J

更新日期：2018-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a high morbidity and disability disease with numerous inflammatory cells infiltrating in interstitial of articular cartilages and bones. As the most abundant inflammatory cells, neutrophil has been reported that their apoptosis changed gradually in the circumstance of RA. Apoptosis, one mo...

journal_title：International immunopharmacology

authors： An Q,Yan W,Zhao Y,Yu K

更新日期：2018-12-01 00:00:00

abstract：:The aim of this study was to evaluate the involvement of both B1 and B2 kinins receptors (B1R and B2R) in the fibroblast proliferation induced by the cytokine tumour necrosis factor (TNF) attempting to establish an in vitro model of wound healing. Murine fibroblasts L-929 were cultivated in 24 wells plaque until total...

journal_title：International immunopharmacology

authors： França AJVBDV,De Faveri R,Nunes R,Steimbach VMB,Santin JR,Quintão NLM

更新日期：2018-12-01 00:00:00

abstract：:In our previous study, we demonstrated that sesamolin can increase the level of cancer cell susceptibility to natural killer (NK) cell mediated cytolysis when it treats cancer cells. The present study attempted to demonstrate the direct influence of sesamolin on NK cells. To achieve the study goal, an NK cell (NK-92MI...

journal_title：International immunopharmacology

authors： Lee SE,Lee JK

更新日期：2018-11-01 00:00:00

abstract：:Therapeutic interventions are still limited in the treatment of liver fibrosis even though an incredible number of publications related to silymarin are produced. This is due to the complex molecular pathogenesis. Several studies pointed to the role of renin-angiotensin system (RAS) in hepatic fibrogenesis. Therefore,...

journal_title：International immunopharmacology

authors： Saber S,Goda R,El-Tanbouly GS,Ezzat D

更新日期：2018-11-01 00:00:00

abstract：:Nerve growth factor (NGF) has been shown to protect the viability of kidney cells in acute phase of renal damage. However, since the half-life of NGF is very short, it is too large to pass the blood-brain barrier and rapidly transported to the liver for catabolizing its use in therapy is limited. 4-Methylcatechol (4MC...

journal_title：International immunopharmacology

authors： Gezginci-Oktayoglu S,Coskun E,Ercin M,Bolkent S

更新日期：2018-11-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a significant public health problem in the United States. Abdominal pain is a major complaint among individuals with IBD. Successful IBD management not only controls enteric inflammation, but also reduces abdominal discomfort. Recently, increased attention has been focused on altern...

journal_title：International immunopharmacology

authors： Wang CZ,Yao H,Zhang CF,Chen L,Wan JY,Huang WH,Zeng J,Zhang QH,Liu Z,Yuan J,Bi Y,Sava-Segal C,Du W,Xu M,Yuan CS

更新日期：2018-11-01 00:00:00

abstract：:To evaluate the effects of pirfenidone in the treatment of HUVEC using an in vitro model and on rat corneal wound healing, edema, cornea neovascularization (CNV) and inflammation after alkali burn in vivo model. In vitro, CCK-8 assay was used to detect the effect of pirfenidone on the viability of HUVECs. The effects ...

journal_title：International immunopharmacology

authors： Jiang N,Ma M,Li Y,Su T,Zhou XZ,Ye L,Yuan Q,Zhu P,Min Y,Shi W,Xu X,Lv J,Shao Y

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Primary biliary cholangitis (PBC) is an autoimmune liver disease characterised by destruction of small intrahepatic bile ducts. Recent studies suggest that miRNAs play a critical role in the pathogenesis of liver diseases. However the role served by miRNAs in the pathogenesis of PBC is still not clear. METH...

journal_title：International immunopharmacology

authors： Song Y,Yang H,Jiang K,Wang BM,Lin R

更新日期：2018-11-01 00:00:00

abstract：:Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) refer to acute and progressive hypoxic respiratory failure caused by non-cardiogenic factors, which is a common condition occurring in critically ill patients with widespread pulmonary inflammation. Use of a single medication or target cannot treat A...

journal_title：International immunopharmacology

authors： Huang Z,Liu H,Zhang X,Wen G,Zhu C,Zhao Y,Niu W,Qin Y,Chen H,Bai C,Liu G

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Although available evidence from clinical trials has shown that immune checkpoint inhibitors (ICIs) combination therapy can lead to a series of immune-related adverse events (irAEs), the overall risk of irAEs on combination therapy has yet not been systematically reported. Therefore, we performed a meta-anal...

journal_title：International immunopharmacology

authors： Zhang B,Wu Q,Zhou YL,Guo X,Ge J,Fu J

更新日期：2018-10-01 00:00:00

abstract：:Influenza viruses cause significant morbidity and mortality and pose a substantial threat to public health. Vaccination represents the principle means of preventing influenza virus infection. Current vaccine approaches are hindered by the need to routinely reformulate vaccine compositions in an effort to account for t...

journal_title：International immunopharmacology

authors： Liu J,Ren Z,Wang H,Zhao Y,Wilker PR,Yu Z,Sun W,Wang T,Feng N,Li Y,Wang H,Ji X,Li N,Yang S,He H,Qin C,Gao Y,Xia X

更新日期：2018-10-01 00:00:00

abstract：:Tree nuts are among "Big Eight" and have been reported globally for causing allergy. Buchanania lanzan (Bl) is one of the major tree nuts consumed by Indian population. However, very little is known about B. lanzan's induced allergic manifestation. Therefore, evaluation of it's allergenic potential was undertaken. Bl-...

journal_title：International immunopharmacology

authors： Kumar S,Sharma A,Gupta RK,Verma AK,Dwivedi PD

更新日期：2018-10-01 00:00:00

abstract：:Neurodegenerative diseases are closely related to neuroinflammation. Drugs targeting inflammation have been proved to be effective in many animal models. Salvianolic acid C (SalC) is a compound isolated from Salvia miltiorrhiza Bunge, a plant with reported effects of inhibiting inflammation. However, the anti-inflamma...

journal_title：International immunopharmacology

authors： Song J,Zhang W,Wang J,Yang H,Zhao X,Zhou Q,Wang H,Li L,Du G

更新日期：2018-10-01 00:00:00

abstract：:Natural killer (NK) cells eliminate cancer cells in a contact-dependent manner. However, how NK cells find cancer cells remain unclear. Here, using time-lapse imaging, we investigated how individual NK cells migrate toward cancer cells. Although naïve B16F10 cancer cells produce low levels of chemokines, IFN-γ-treated...

journal_title：International immunopharmacology

authors： Kim J,Kim JS,Lee HK,Kim HS,Park EJ,Choi JE,Choi YJ,Shin BR,Kim EY,Hong JT,Kim Y,Han SB

更新日期：2018-10-01 00:00:00

abstract：:B-cell lymphoma remains one of the most refractory tumors, and as such the development of novel treatment approaches, such as antibody-drug conjugates (ADCs), is required. To improve the stability and homogeneity of the ADCs, a humanized anti-CD19 monoclonal antibody (RC58) was developed in the present study. RC58 was...

journal_title：International immunopharmacology

authors： Li Z,Wang M,Yao X,Li H,Li S,Liu L,Yu D,Li X,Fang J,Huang C

更新日期：2018-09-01 00:00:00

abstract：:Curcumin shows protective effects on various diseases due to its anti-inflammatory and anti-oxidative functions; however, its effect on organ transplantation has not been fully elucidated. To understand its role in liver ischemia/reperfusion (I/R) injury, we studied its impact on orthotopic liver transplantation (OLT)...

journal_title：International immunopharmacology

authors： Liu Y,Zhang W,Cheng Y,Miao C,Gong J,Wang M

更新日期：2018-09-01 00:00:00

abstract：:Monocytes recruited and adhering to the inflamed arteries are crucial for atherosclerosis development. Here, we report the role of zinc (Zn2+) homeostasis in monocyte adhesion and recruitment. By comparing the expression levels of Zn2+ transporters between non-adhering and adhering monocytes, we found that the Zn2+ im...

journal_title：International immunopharmacology

authors： Cheng G,Chang FJ,You PH,Lin J,Huang XY,Wu HY,Yan L,Deng JZ,You HJ,Sun CF

更新日期：2018-09-01 00:00:00

abstract：:1,25-dihydroxyvitaminD3 [1,25(OH)2D3] modulates both the innate and adaptive immunity in tuberculosis. We explored the effect of 1,25(OH)2D3 on cytolytic molecules like perforin, granulysin, and granzyme-B in T-cells and natural killer cells during M. tuberculosis (Mtb) infection. Peripheral blood mononuclear cells (P...

journal_title：International immunopharmacology

authors： Afsal K,Selvaraj P,Harishankar M

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Human recombinant interferon beta (IFN-β) is one of the first line treatments for Relapsing-Remitting Multiple Sclerosis (RRMS). However, the production of neutralizing antibodies (NAb) can impair its function. The aim of this study was to investigate the production of neutralizing antibodies against Rebif...

journal_title：International immunopharmacology

authors： Shokrollahi Barough M,Ashtari F,Sadat Akhavi M,Asghari N,Mosayebi G,Mirmohammadkhani M,Kokhaei N,Bahraminia F,Ajami A,Kokhaei P

更新日期：2018-09-01 00:00:00

abstract：:Acute liver injury (ALI) is a dramatic liver disease characterized by large areas of inflammation in the liver. This study aimed to investigate the protective effects of ginsenoside Rg1 (Rg1), a biologically active component in Panax ginseng, on lipopolysaccharide/d-galactosamine (LPS/D-GalN)-induced ALI in mice, and ...

journal_title：International immunopharmacology

authors： Ning C,Gao X,Wang C,Huo X,Liu Z,Sun H,Yang X,Sun P,Ma X,Meng Q,Liu K

更新日期：2018-08-01 00:00:00

abstract：:Inflammatory factors play an important role in the pathogenesis of diabetic vascular complications. Considerable interest in the therapeutic potential of mesenchymal stem cells (MSCs) has recently arisen. The purposes of this study were to investigate the effects of MSCs on endothelial cells under inflammatory conditi...

journal_title：International immunopharmacology

authors： Shi M,Yuan Y,Liu J,Chen Y,Li L,Liu S,An X,Luo R,Long D,Chen B,Du X,Cheng J,Lu Y

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Regulatory T cells (Tregs) are thought to play a modulatory role in immune responses and to improve outcomes after ischemic stroke. Thus, various strategies for increasing Tregs in animal models of ischemic stroke have yielded successful results. The aim of this study was to examine the potential effect of p...

journal_title：International immunopharmacology

authors： Noh MY,Lee WM,Lee SJ,Kim HY,Kim SH,Kim YS

更新日期：2018-07-01 00:00:00

abstract：:Interaction between Toll-like receptor (TLR) and Notch signaling contributes to inflammatory response in nephropathy and fungicidal infection, however, the role of this crosstalk remains not fully elucidated in enterovirus 71 (EV71)-induced hand, foot, and mouth disease (HFMD). The aim of this study was to investigate...

journal_title：International immunopharmacology

authors： Hao J,Li P,Tian Y,Wang Y,Li S,Wang L,Li S

更新日期：2018-07-01 00:00:00

abstract：:Myocardial fibrosis plays a central role in the development of heart failure. It has been shown that recurrent exposure to subclinical lipopolysaccharide (LPS) increases mortality and induces cardiac fibrosis in mice, which is not mediated by the common renin-angiotensin system. LPS increased NADPH oxidase2 (NOX2) in ...

journal_title：International immunopharmacology

authors： Huang L,Zhu J,Zheng M,Zou R,Zhou Y,Zhu M

更新日期：2018-07-01 00:00:00

abstract：:An expansion of regulatory T cells (Tregs) in ankylosing spondylitis (AS) was observed. However, AS patients continue to exhibit aberrant inflammation. In this study, we collected PBMCs from 26 AS patients and 26 healthy controls, and investigated the functional capacity of Treg cells from these subjects. In AS patien...

journal_title：International immunopharmacology

authors： Wang M,Liu C,Bond A,Yang J,Zhou X,Wang J,Ji B

更新日期：2018-06-01 00:00:00

abstract：:The immune system is a very diverse system of the host that evolved during evolution to cope with various pathogens present in the vicinity of environmental surroundings inhabited by multicellular organisms ranging from achordates to chordates (including humans). For example, cells of immune system express various pat...

journal_title：International immunopharmacology

authors： Vijay K

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:The purpose of this study is to evaluate the therapeutic efficacy and the role of PD-1/PD-L1 pathway in tongue squamous cell carcinoma (TSCC) patients treated with radical operation combined with chemotherapy and improving cytokine induced killer cells (iCIKs) transfer. METHODS:Thirteen patients who receive...

journal_title：International immunopharmacology

authors： Huang X,Zhang J,Li X,Huang H,Liu Y,Yu M,Zhang Y,Wang H

更新日期：2018-06-01 00:00:00

abstract：:The anti-inflammatory, immunomodulatory, and anticancer effects of micheliolide (MCL) isolated from Michelia champaca were previously reported, but its role and underlying mechanisms in relieving liver steatosis remain unclear. Herein, we investigated the effects of MCL on hepatic steatosis using a db/db mouse model a...

journal_title：International immunopharmacology

authors： Zhong J,Gong W,Chen J,Qing Y,Wu S,Li H,Huang C,Chen Y,Wang Y,Xu Z,Liu W,Li H,Long H

更新日期：2018-06-01 00:00:00

abstract：:IL-36 cytokines (IL-36Ra, IL-36α, IL-36β and IL-36γ) belong to the IL-1 family and have been linked to several autoimmune diseases. However, little is known about the relationships between systemic lupus erythematosus (SLE) and IL-36 cytokines. In this study, serum IL-36 cytokine levels were determined by enzyme-linke...

journal_title：International immunopharmacology

authors： Mai SZ,Li CJ,Xie XY,Xiong H,Xu M,Zeng FQ,Guo Q,Han YF

更新日期：2018-05-01 00:00:00

abstract：:Azithromycin is a potent agent that prevents airway remodeling. In this study, we hypothesized that azithromycin (35 mg/kg orally) alleviated airway remodeling through suppression of epithelial-to-mesenchymal transition (EMT) via downregulation of transforming growth factor-beta 1 (TGF-β1)/receptor for activated C-kin...

journal_title：International immunopharmacology

authors： Pu Y,Liu Y,Liao S,Miao S,Zhou L,Wan L

更新日期：2018-05-01 00:00:00

abstract：:In recent years, using genetic engineering and bioengineering techniques, Bifidobacterium as a carrier to express specific functions of the protein or polypeptide, has become a new treatment for disease. Ulcerative colitis (UC) is a type of inflammatory bowel diseases (IBD). Although the cause of this inflammatory dis...

journal_title：International immunopharmacology

authors： Liu M,Li S,Zhang Q,Xu Z,Wang J,Sun H

更新日期：2018-04-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are responsible for high mortality rates in critical patients. Despite >50 years of intensive research, there is no pharmacologically effective treatment to treat ALI. PPARs agonists, chemically named thiazolidinediones (TZDs) have emerged as poten...

journal_title：International immunopharmacology

authors： Santos LAMD,Rodrigues GB,Mota FVB,França MER,de Souza Barbosa KP,Oliveira WH,Rocha SWS,Lós DB,Silva AKS,Silva TGD,Peixoto CA

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To compare anti-malondialdehyde-acetaldehyde (MAA) antibody concentrations between rheumatoid arthritis (RA) patients and healthy and rheumatic disease controls. METHODS:Anti-MAA antibody (IgA, IgM, IgG) was measured using ELISA and banked serum from patients with RA (n = 284), osteoarthritis (OA, n = 330), ...

journal_title：International immunopharmacology

authors： Mikuls TR,Duryee MJ,England BR,Anderson DR,Hearth-Holmes M,Su K,Michaud K,Payne JB,Sayles H,Hunter C,McGowan JD,Klassen LW,Thiele GM

更新日期：2018-03-01 00:00:00

abstract：:MALT lymphoma-translocation protein 1 (Malt1) protease activity is triggered by stimulation of various immune receptors. Activation of Malt1 protease induces cleavage of negative regulators for immune responses, resulting in lymphocytes activation. Although Malt1 protease mediates the signaling process downstream of t...

journal_title：International immunopharmacology

authors： Nakamura Y,Yokoyama K,Igaki K,Tsuchimori N

更新日期：2018-03-01 00:00:00

abstract：:As one specialized subset of regulatory T cells (Tregs), follicular regulatory T cells (TFR) could suppress follicular helper T cells (TFH) and B cells in germinal centers to maintain immune homeostasis. The unbalance of TFR and TFH cells could result in abnormal germinal center responses and contribute to pathogenesi...

journal_title：International immunopharmacology

authors： Liu C,Wang D,Song Y,Lu S,Zhao J,Wang H

更新日期：2018-03-01 00:00:00